Endocrine Abstracts

Background: Adrenal incidentalomas (AI) have an increasing prevalence during last decades, probably due to the extended use of new imaging techniques and longer life expectancy. Adrenal hormonal hypersecretion, even subclinical, is probably related to cardiovascular disease (CVD).Methods: We evaluated 100 patients with adrenal masses, incidentally discovered in imaging techniques performed for non adrenal disorders (67 Female, 33 Male, mean 58.1±12....

Introduction: Pembrolizumab is a programmed death receptor-1(PD-1)-blocking antibody, used in a variety of advanced malignant tumors with promising results, although adverse events are not rare.Case report: We present the case of an adult female, with negative personal and family history of autoimmune diseases, who developed malignant superficial melanoma of right wrist 6 years ago. She was initially treated with surgical resection (lesion and ipsilatera...

Introduction: Adrenal crisis due to primary adrenal insufficiency may result in severe morbidity and mortality if undiagnosed or ineffectively treated. Main manifestations are hypotension (>90%), hyponatremia (70–80%), and hyperkalemia (30–40%), while hypoglycemia is rare. An unusual case of a septic patient with hypokalemia and hypomagnesemia with hypoglycemic coma as first manifestation of acute adrenal insufficiency is presented.Case pre...

Background: Adrenal Incidentaloma’s (AI) incidence has been increased 10-fold in the past two decades and more specifically, up to 7% in the general population and up to 9% in elderly patients. Determining whether an adrenal mass is malignant or hormonally active is of great clinical and socioeconomical importance, in order to select the best medical approach and follow up. Artificial Intelligence techniques could provide useful clinical tools for predicting the nature of...

IntroductionAlemtuzumab is an anti-CD52 antibody, leading to lysis and transient depletion of T and B lymphocytes. Its therapeutic effect is mediated by the alteration in immune repertoire that accompanies subsequent lymphocyte reconstitution. It is mainly used for the treatment of relapsing–remitting multiple sclerosis (RRMS). Common side effects are autoimmune diseases, including thyroid disease (>40%), immune thrombocytopenia (IT...

Introduction: Non-celiac gluten sensitivity (NCGS) belongs to gluten-related disorders. Patients with NCGS develop a variety of intestinal and/or extraintestinal symptoms such as abdominal pain, bloating, bowel habit abnormalities, nausea, gastroesophageal reflux disease and aphthous stomatitis, that improve when gluten is removed from the diet. The diagnosis is made after exclusion of coeliac disease and wheat allergy. Although thyroxine malabsorption has been described in pa...

Background: Diabetic ketoacidosis (DKA) has been associated with severe hemolysis in patients with Glucose-6-phosphate dehydrogenase (G6PD) deficiency after restoration of euglycemia. Less than 30 cases have been reported so far. The exact mechanism is not fully understood.Case presentation: A 35-year-old African American man presented to the emergency department with polyuria, polydipsia, abdominal pain and weight loss the last 15 days. Physical examina...

Introduction: Mutations in the variable number of tandem repeats (VNTR) region of the carboxyl-ester lipase (CEL) gene can cause a very rare type of maturity-onset diabetes of the young (MODY 8) characterized by insulinopenic diabetes mellitus (DM) in early adulthood and slowly progressive exocrine pancreatic dysfunction. We present the unusual case of a patient with heterozygosity in a variant of CEL outside the VNTR region suffering from DM, dyslipidemia and exocrin...

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease with multisystem involvement and varied presentation but its association with adrenal insufficiency is rarely reported.Case presentation: A 30-year-old female presented to the emergency department with fever, lethargy and syncopal episodes during the last 48 h. She complained of general weakness, abdominal pain, nausea, vomiting, weight loss and anorexia for five months. Symptoms det...

Aim: To explore the epidemiological characteristics and symptoms of psychological distress of well-controlled endocrine patients without a diagnosis of a psychiatric disorder attending the Endocrine outpatient clinic of the University Hospital, Heraklion, Crete, Greece during the COVID-19 pandemic. Methods: Eighty-four patients participated by completing questionnaires about demographics, endocrine diagnosis, covid infection, preventive measures, vaccination s...